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The chromatin factors SET-26 and HCF-1 oppose the histone deacetylase HDA-1 in longevity and gene regulation in <i>C. elegans</i>

2023-03-23

Abstract excerpt

SET-26, HCF-1, and HDA-1 are highly conserved chromatin factors with key roles in development and aging. Here we present mechanistic insights into how these factors regulate gene expression and modulate longevity in C. elegans . We show that SET-26 and HCF-1 cooperate to regulate a common set of genes, and both antagonize the histone deacetylase HDA-1 to limit longevity. We propose a model in which SET-26 recruit...

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Identifiers and source

Literature Corpus work
83713d69-890d-5e6c-892e-c60e7b49eb94
DOI
10.1101/2023.03.20.531974
Open publication

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