Article

Molecular Dynamics simulations of Alzheimer’s variants, R47H and R62H, in TREM2 provide evidence for structural alterations behind functional changes

2019-01-31

Abstract excerpt

There is strong evidence supporting the association between Alzheimer’s disease (AD) and protein-coding variants, R47H and R62H in TREM2 . The TREM2 protein is an immune receptor found in brain microglia. A structural alteration could therefore have a large effect on the protein. Crystallised structures were used as a base for both WT and mutated proteins. These subjected to 300ns of molecular dynamic simulation...

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Literature Corpus work: 780ffe43-c515-5a2f-9f5c-e45f2adf6898
DOI: 10.1101/536540

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