Article

NVUAtlas: A Comprehensive Single-Nucleus RNA-Seq Resource for the Human Neurovascular Unit in Alzheimer’s Disease

2025-12-04

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Neurovascular unit (NVU) dysfunction is being recognized as one of the earliest contributors to Alzheimer’s disease (AD) pathogenesis. However, systematic investigation of NVU dysfunction is currently limited by lack of access to molecular level information due to underrepresentation of vascular and mural cells in standard single-nucleus RNA sequencing (snRNA-seq) datasets....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7422c8ae-ca41-5e37-ab77-7797a7856601
DOI: 10.64898/2025.12.03.692162

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

NVUAtlas: A Comprehensive Single-Nucleus RNA-Seq Resource for the Human Neurovascular Unit in Alzheimer’s DiseaseDOI 10.64898/2025.12.03.692162Read

Single Nuclei Transcriptome Reveals Perturbed Brain Vascular Molecules in Alzheimer’s DiseaseSemantic proximity Read

A human brain vascular atlas reveals diverse cell mediators of Alzheimer’s disease riskSemantic proximity Read

Angiopoietin signalling is a central axis of amyloid-driven vascular dysfunction in Alzheimer’s diseaseSemantic proximity Read

Accelerated aging-related transcriptome alterations in neurovascular unit cells in the brain of Alzheimer’s diseaseSemantic proximity Read

Multimodal analysis identifies pericyte-centered signaling programs altered by sex and brain region in Alzheimer’s DiseaseSemantic proximity Read

Single-cell multi-region dissection of brain vasculature in Alzheimer’s DiseaseSemantic proximity Read

A single nuclear transcriptomic characterisation of mechanisms responsible for impaired angiogenesis and blood-brain barrier function in Alzheimer’s diseaseSemantic proximity Read

Single nuclear transcriptional signatures of dysfunctional brain vascular homeostasis in Alzheimer’s diseaseSemantic proximity Read

Shared and disease-specific human brain vascular signatures in Alzheimer’s disease, frontotemporal dementia, and Huntington’s diseaseSemantic proximity Read

Endothelial Cells are Heterogeneous in Different Brain Regions and are Dramatically Altered in Alzheimer’s DiseaseSemantic proximity Read

Single‐nucleus transcriptome analysis reveals disease‐ and regeneration‐associated endothelial cells in white matter vascular dementiaSemantic proximity Read

Transcriptomic Evidence of MAS1 Receptor Dysregulation and a Failed Compensatory State in Human Vascular Cognitive ImpairmentSemantic proximity Read