Article

Single nuclear transcriptional signatures of dysfunctional brain vascular homeostasis in Alzheimer’s disease

2021-10-28

Abstract excerpt

Brain perfusion and normal blood brain barrier integrity are reduced early in Alzheimer’s disease (AD). We performed single nucleus RNA sequencing of vascular cells isolated from AD and control brains to characterise pathological transcriptional signatures. We found that endothelial cells (EC) are enriched for expression of genes associated with susceptibility to AD. EC transcriptional signatures identified mechan...

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Literature Corpus work: 587ef5a7-35d7-5f8c-bb57-f58517bb0034
DOI: 10.1101/2021.10.27.465860

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