Article

Transcription factors overcome the repressive impact of Polycomb-associated methylation in tumors

2025-05-19

Abstract excerpt

DNA methylation is a key epigenetic regulator often disrupted in cancer, yet how promoter methylation dynamics translate into transcriptional changes during cancer progression remains incompletely understood. Here, we employed targeted bisulfite sequencing and RNA-seq on paired tumor and non-tumor tissues from 80 Korean colorectal cancer (CRC) patients to map promoter methylation and gene expression dynamics. Prom...

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Literature Corpus work: 8026ca1b-f667-5d63-9c92-3c135bbb0b3e
DOI: 10.1101/2025.05.15.654174

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