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Article

Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer.

Genome research - 1 Apr 2010

Teschendorff Andrew E, Menon Usha, Gentry-Maharaj Aleksandra, Ramus Susan J, Weisenberger Daniel J, Shen Hui, Campan Mihaela, Noushmehr Houtan, Bell Christopher G, Maxwell A Peter, Savage David A, Mueller-Holzner Elisabeth, Marth Christian, Kocjan Gabrijela, Gayther Simon A, Jones Allison, Beck Stephan, Wagner Wolfgang, Laird Peter W, Jacobs Ian J, Widschwendter Martin

Abstract excerpt

Polycomb group proteins (PCGs) are involved in repression of genes that are required for stem cell differentiation. Recently, it was shown that promoters of PCG target genes (PCGTs) are 12-fold more likely to be methylated in cancer than non-PCGTs. Age is the most important demographic risk facto...

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Identifiers

PMID: 20219944
DOI: 10.1101/gr.103606.109
PMCID: PMC2847747

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20219944-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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