Article
Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network
29 Feb 2016
Abstract excerpt
Malignant gliomas constitute one of the most significant areas of unmet medical need, owing to the invariable failure of surgical eradication and their marked molecular heterogeneity. Accumulating evidence has revealed a critical contribution by the Polycomb axis of epigenetic repression. However, a coherent understanding of the regulatory networks affected by Polycomb during gliomagenesis is still lacking. Here...
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