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Article

Chromatin regulators with tumor suppressor properties and their alterations in human cancers.

Epigenomics - 1 Oct 2012

Shu Xing-Sheng, Li Lili, Tao Qian

Abstract excerpt

Key components of the cell epigenome include DNA CpG methylation profile and chromatin modification patterns. Chromatin regulators act as master controllers of gene transcription in normal cells through regulation of histone modifications and chromatin remodeling. During human cancer pathogenesis, the functions of chromatin regulators are frequently disrupted by genetic mutations and/or epigenetic alterations,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomal Proteins, Non-Histone

Share to Genes, Neoplasm

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Source

Identifiers

PMID: 23130835
DOI: 10.2217/epi.12.50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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