Article

Alternative promoters in CpG depleted regions pervasively account for epigenetic misregulation of cancer transcriptomes

2022-08-05

Abstract excerpt

Eukaryotic genes are regulated by multiple alternative promoters with distinct expression patterns. In cancer, alternative promoters are pervasively utilized, but our understanding of the mechanism of activation and how their regulatory architecture differs from reference promoters remains elusive. We analyzed 100 CAGE-seq libraries from HCC patients and annotated 4083 alternative promoters in 2926 multi-promoter...

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Literature Corpus work: 99166667-6936-5de9-944b-8cea859c887b
DOI: 10.1101/2022.08.02.502575

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