Article

Adiponectin Receptor Fragmentation in Mouse Models of Type 1 and Type 2 Diabetes

2019-11-20

Abstract excerpt

The protein hormone adiponectin regulates glucose and fatty acid metabolism by binding to two PAQR-family receptors (AdipoR1 and AdipoR2). Both receptors feature a C-terminal segment which is released by proteolysis to form a freely-circulating C-terminal fragment (CTF) found in the plasma of normal individuals but not in some undefined diabetes patients. The AdipoR1-CTF 344-376 is a competitive inhibitor of tumo...

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Literature Corpus work: 801f5385-8634-52a4-83a4-daa5a32b7d75
DOI: 10.1101/849000

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