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Neurokinin-1 Receptor Activation Protects Against Cardiac Fibrosis, Inflammation, and Diastolic Dysfunction in Type 2 Diabetic Mice

2025-09-22

Abstract excerpt

<h4>Background: </h4> and Purpose: The pathogenesis of type 2 diabetes mellitus (T2DM)-induced cardiomyopathy involves cardiac fibrosis that leads to diastolic dysfunction. We established that replacement of lost substance P (SP) that occurs in T2DM reduces cardiac fibrosis and decreases inflammation in T2DM mice and non-human primates. This study aimed to identify the specific anti-fibrotic SP receptor. Experime...

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Literature Corpus work
6e45a1e9-7c02-503a-9ad3-513584d4fa82
DOI
10.22541/au.175854449.90395737/v1
Open publication

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Neurokinin-1 Receptor Activation Protects Against Cardiac Fibrosis, Inflammation, and Diastolic Dysfunction in Type 2 Diabetic MiceDOI 10.22541/au.175854449.90395737/v1
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