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Potential Adiponectin Receptor Response Modifier Therapeutics

13 Aug 2019

Abstract excerpt

Many human diseases may benefit from adiponectin replacement therapy, but due to pharmacological disadvantages of the intact protein, druggable options focus on peptidic and small molecule agonists of the adiponectin receptor. Peptide-based adiponectin replacement drug leads are derived from, or resemble, the active site of globular adiponectin. ADP355, the first-in-class such peptide, exhibits low nanomolar...

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PMID: 31456747
DOI: 10.3389/fendo.2019.00539

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