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Article

The C3a anaphylatoxin receptor is a key mediator of insulin resistance and functions by modulating adipose tissue macrophage infiltration and activation.

Diabetes - 1 Sept 2009

Mamane Yaël, Chung Chan Chi, Lavallee Genevieve, Morin Nicolas, Xu Li-Jing, Huang JingQi, Gordon Robert, Thomas Winston, Lamb John, Schadt Eric E, Kennedy Brian P, Mancini Joseph A

Abstract excerpt

OBJECTIVE: Significant new data suggest that metabolic disorders such as diabetes, obesity, and atherosclerosis all posses an important inflammatory component. Infiltrating macrophages contribute to both tissue-specific and systemic inflammation, which promotes insulin resistance. The complement cascade is involved in the inflammatory cascade initiated by the innate and adaptive immune response. A mouse genomic...

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Share to 3T3-L1 Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19581423
DOI: 10.2337/db09-0323
PMCID: PMC2731537

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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