Article

<i>EctoShed</i> : A novel <i>Gene Delivery Platform for Functional Analysis of Adipocyte-Shed Proteoforms</i>

2025-10-15

Abstract excerpt

<h4>Objective</h4> The proteolytic cleavage of membrane-bound proteins, ectodomain shedding, functionally expands the reservoire of proteins/peptides available for endocrine crosstalk, and metabolic regulation. However, the functional understanding of secreted proteoforms, including whether they act synergistically or antagonistically with their membrane precursors, is often unknown. We aimed to develop a novel v...

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Literature Corpus work: 00361ac1-9f57-5b80-96b2-bdd8567d2764
DOI: 10.1101/2025.10.14.682314

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