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Article

Systemic anti-TNFalpha treatment restores diabetes-impaired skin repair in ob/ob mice by inactivation of macrophages.

The Journal of investigative dermatology - 1 Sept 2007

Goren Itamar, Müller Elke, Schiefelbein Dana, Christen Urs, Pfeilschifter Josef, Mühl Heiko, Frank Stefan

Abstract excerpt

To date, diabetes-associated skin ulcerations represent a therapeutic problem of clinical importance. The insulin-resistant type II diabetic phenotype is functionally connected to obesity in rodent models of metabolic syndrome through the release of inflammatory mediators from adipose tissue. Her...

Read the complete abstract on PubMed

Topics

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Share to Adipose Tissue
Share to Diabetes Complications
Share to Diabetes Mellitus, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macrophages

Share to Mice, Obese

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Share to Wound Healing

Source

Identifiers

PMID: 17460730
DOI: 10.1038/sj.jid.5700842

Genes

EGF
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17460730-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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