Article
Adipokine and insulin profiles distinguish diabetogenic and non-diabetogenic obesities in mice.
Obesity (Silver Spring, Md.) - 1 Aug 2007
Leiter Edward H, Reifsnyder Peter C, Xiao Qiang, Mistry Jehangir
Abstract excerpt
OBJECTIVE: To use longitudinal profiling of plasma adipokines to distinguish diabetogenic vs. non-diabetogenic obesity syndrome in two new mouse models of polygenic obesity. RESEARCH METHODS AND PROCEDURES: Male mice of the NONcNZO5 strain develop a polygenic obesity syndrome uncomplicated by diabetes, whereas NONcNZO10 males develop a comparable polygenic obesity that precipitates type 2 diabetes. A multiplex...
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