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Article

Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin.

The Journal of biological chemistry - 10 Oct 2003

Waki Hironori, Yamauchi Toshimasa, Kamon Junji, Ito Yusuke, Uchida Shoko, Kita Shunbun, Hara Kazuo, Hada Yusuke, Vasseur Francis, Froguel Philippe, Kimura Satoshi, Nagai Ryozo, Kadowaki Takashi

Abstract excerpt

Adiponectin is an adipocyte-derived hormone, which has been shown to play important roles in the regulation of glucose and lipid metabolism. Eight mutations in human adiponectin have been reported, some of which were significantly related to diabetes and hypoadiponectinemia, but the molecular mechanisms of decreased plasma levels and impaired action of adiponectin mutants were not clarified. Adiponectin...

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PMID: 12878598
DOI: 10.1074/jbc.M300365200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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