Article
Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: I. Pathophysiological analysis.
Diabetes - 1 Sept 2005
Lee Chul-Ho, Reifsnyder Peter C, Naggert Jürgen K, Wasserfall Clive, Atkinson Mark A, Chen Jing, Leiter Edward H
Abstract excerpt
A spontaneous single-base mutation in the leptin receptor of type 1 diabetes-prone NOD/LtJ mice (designated as Lepr(db-5J)) produced a glycine640valine transversion in the extracellular domain. All mutant mice became obese and hyperinsulinemic at weaning, with 70-80% developing early-onset hyperglycemia. However, these obese diabetic mice continued to gain weight without insulin therapy. Spontaneous diabetes...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.