Article

Systematic disease-agnostic identification of therapeutically actionable targets using the genetics of human plasma proteins

2023-06-05

Abstract excerpt

Proteome-wide Mendelian randomization (MR) has emerged as a promising approach in uncovering novel therapeutic targets. However, genetic colocalization analysis has revealed that a third of MR associations lacked a shared causal signal between the protein and disease outcome, raising questions about the effectiveness of this approach. The impact of proteome-wide MR, stratified by cis-trans status, in the presence...

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Literature Corpus work: 7fd5cc77-33de-5880-aefe-369cf4f6fc34
DOI: 10.1101/2023.06.01.23290252

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