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Article

Employing plasma proteins in proteomic Mendelian randomization analysis to identify therapeutic targets for duodenal ulcer.

Medicine - 31 Oct 2025

Luo Xu, Luo Dan, Liu Chenhao, Zhang Huize, Long Mingyue, Cao Simin, Liu Yi

Abstract excerpt

Proteomics serves as a primary source of therapeutic targets. In this study, we performed a Mendelian randomization (MR) analysis within the proteomic scope to identify candidate protein markers and potential therapeutic targets for duodenal ulcer (DU). This study utilized MR and co-localization analysis within the proteomic framework. Data on 2088 plasma proteins were carefully collected from a study that...

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Identifiers

PMID: 41261599
DOI: 10.1097/MD.0000000000045093
PMCID: PMC12582692

Genes

EPHB4
FLT4
REG1B
DPEP2
IL6ST
QSOX2
FAM3D
GOLM1
IL1R1
IGSF3
SEMA6A

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