Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Systematic proteome-wide Mendelian randomization using the human plasma proteome to identify therapeutic targets for lung adenocarcinoma.

Journal of translational medicine - 4 Apr 2024

Zhang Long, Xiong Yajun, Zhang Jie, Feng Yuying, Xu Aiguo

Abstract excerpt

BACKGROUND: Lung adenocarcinoma (LUAD) is the predominant histological subtype of lung cancer and the leading cause of cancer-related mortality. Identifying effective drug targets is crucial for advancing LUAD treatment strategies. METHODS: This study employed proteome-wide Mendelian randomization (MR) and colocalization analyses. We collected data on 1394 plasma proteins from a protein quantitative trait loci...

Topics

Humans
Proteome
Bayes Theorem
Genome-Wide Association Study
Mendelian Randomization Analysis
Adenocarcinoma of Lung
Lung Neoplasms
Blood Proteins
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 38576019
DOI: 10.1186/s12967-024-04919-z
PMCID: PMC10993587

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Systematic proteome-wide Mendelian randomization using the human plasma proteome to identify therapeutic targets for lung adenocarcinoma.PMID 38576019Read ↗

Systematic Mendelian randomization using the human plasma proteome to identify therapeutic targets for lung adenocarcinomaSemantic proximity Read ↗

Identification of promising lung cancer drug targets from human plasma proteins: Mendelian randomization, single-cell RNA sequencing analysisSemantic proximity Read ↗

Identifying new biomarkers and potential therapeutic targets for breast cancer through the integration of human plasma proteomics: a Mendelian randomization study and colocalization analysis.Semantic proximity Read ↗

Therapeutic targets for lung cancer: genome-wide Mendelian randomization and colocalization analysesSemantic proximity Read ↗

Integration of lung tissue proteomics and genome-wide association data to identify lung cancer susceptibility proteins and potential drug targetsSemantic proximity Read ↗

Proteome-wide Mendelian randomization analyses to identify potential therapeutic targets for lung function and respiratory diseaseSemantic proximity Read ↗

Identification of Emerging Drug Targets for Pulmonary Functions Through Mendelian Randomization Analysis of the Plasma ProteomeSemantic proximity Read ↗

Exploring the cross-cancer effect of circulating proteins and discovering potential intervention targets for 13 site-specific cancers.Semantic proximity Read ↗

Cross-ancestry proteome-wide Mendelian randomization prioritizes 12 plasma protein candidates for breast cancer riskSemantic proximity Read ↗

Identification of Candidate Lung Function-Related Plasma Proteins to Pinpoint Drug Targets for Common Pulmonary Diseases: A Comprehensive Multi-Omics Integration AnalysisSemantic proximity Read ↗

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases.Semantic proximity Read ↗

Machine learning-based proteogenomic data modeling identifies circulating plasma biomarkers for early detection of lung cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.