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Article

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

2019-05-05

Abstract excerpt

The human proteome is a major source of therapeutic targets. Recent genetic association analyses of the plasma proteome enable systematic evaluation of the causal consequences of variation in plasma protein levels. Here, we estimated the effects of 1002 proteins on 225 phenotypes using two-sample Mendelian randomization (MR) and colocalization. Of 413 associations supported by evidence from MR, 130 (31.5%) were no...

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Literature Corpus work
679a3224-4f3a-55c2-b5c8-32a6fbe8f07c
DOI
10.1101/627398
Open publication

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Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseasesDOI 10.1101/627398
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