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Article

Therapeutic targets for inflammatory bowel disease: proteome-wide Mendelian randomization and colocalization analyses.

EBioMedicine - 1 Mar 2023

Chen Jie, Xu Fengzhe, Ruan Xixian, Sun Jing, Zhang Yao, Zhang Han, Zhao Jianhui, Zheng Jie, Larsson Susanna C, Wang Xiaoyan, Li Xue, Yuan Shuai

Abstract excerpt

BACKGROUND: Identifying new drug targets for inflammatory bowel disease (IBD) is urgently needed. The proteome is a major source of therapeutic targets. We conducted a proteome-wide Mendelian randomization (MR) and colocalization analyses to identify possible targets for IBD. METHODS: Summary-level data of 4907 circulating protein levels were extracted from a large-scale protein quantitative trait loci study...

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Source

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Identifiers

PMID: 36857861
DOI: 10.1016/j.ebiom.2023.104494
PMCID: PMC9986512

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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