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Article

Systematic disease-agnostic identification of therapeutically actionable targets using the genetics of human plasma proteins.

2023-07-03

Abstract excerpt

<title>Abstract</title> <p>Proteome-wide Mendelian randomization (MR) has emerged as a promising approach in uncovering novel therapeutic targets. However, genetic colocalization analysis has revealed that a third of MR associations lacked a shared causal signal between the protein and disease outcome, raising questions about the effectiveness of this approach. The impact of proteome-wide MR, stratified by cis-tr...

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Literature Corpus work
9dd7e7b2-f866-56f0-8b7a-771b41e22921
DOI
10.21203/rs.3.rs-2978334/v1
Open publication

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Systematic disease-agnostic identification of therapeutically actionable targets using the genetics of human plasma proteins.DOI 10.21203/rs.3.rs-2978334/v1
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