Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Culture Variabilities of Human iPSC-Derived Cerebral Organoids Are a Major Issue for the Modelling of Phenotypes Observed in Alzheimer's Disease.

Stem cell reviews and reports - 1 Feb 2022

Hernández Damián, Rooney Louise A, Daniszewski Maciej, Gulluyan Lerna, Liang Helena H, Cook Anthony L, Hewitt Alex W, Pébay Alice

Abstract excerpt

Apolipoprotein E (APOE) is the most important susceptibility gene for late onset of Alzheimer's disease (AD), with the presence of APOE-ε4 associated with increased risk of developing AD. Here, we reprogrammed human fibroblasts from individuals with different APOE-ε genotypes into induced pluripotent stem cells (iPSCs), and generated isogenic lines with different APOE profiles. Following characterisation of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Amyloid beta-Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoprotein E4

Share to Apolipoproteins E

Share to Induced Pluripotent Stem Cells

Share to Organoids

Share to Phenotype

Source

Identifiers

PMID: 33725267
DOI: 10.1007/s12015-021-10147-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Culture Variabilities of Human iPSC-Derived Cerebral Organoids Are a Major Issue for the Modelling of Phenotypes Observed in Alzheimer's Disease.PMID 33725267Read ↗

Investigating the role of APOE: limitations of human pluripotent stem cell-derived cerebral organoidsSemantic proximity Read ↗

Reprogramming the Brain—iPSC Models Illuminating the Pathogenesis and Treatment of Alzheimer’s Disease and Other DementiasSemantic proximity Read ↗

APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids.Semantic proximity Read ↗

Generation of a set of isogenic iPSC lines carrying all APOE genetic variants (Ɛ2/Ɛ3/Ɛ4) and knock-out for the study of APOE biology in health and disease.Semantic proximity Read ↗

Chimeric cerebral organoids reveal the essentials of neuronal and astrocytic APOE4 for Alzheimer’s tau pathologySemantic proximity Read ↗

<i>APOE</i> deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoidsSemantic proximity Read ↗

Using human induced pluripotent stem cells (hiPSCs) to investigate the mechanisms by which Apolipoprotein E (APOE) contributes to Alzheimer’s disease (AD) riskSemantic proximity Read ↗

Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer's Disease Phenotypes.Semantic proximity Read ↗

Neurodegeneration in a dish: advancing human stem-cell-based models of Alzheimer's disease.Semantic proximity Read ↗

Modeling Alzheimer’s Disease with APOE4 Neuron-Glial Brain Assembloids Reveals IGFBPs as Therapeutic TargetsSemantic proximity Read ↗

Dissecting the complexities of Alzheimer disease with in vitro models of the human brain.Semantic proximity Read ↗

Engineered Cerebral Organoids Recapitulate Adult Tau Expression and Disease-relevant Changes in Tau SplicingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.