Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Detection of all adult Tau isoforms in a 3D culture model of iPSC-derived neurons

23 Aug 2019

Abstract excerpt

Tauopathies are a class of neurodegenerative diseases characterized by the presence of pathological intracellular deposits of Tau proteins. Six isoforms of Tau are expressed in the adult human brain, resulting from alternative splicing of the MAPT gene. Tau splicing is developmentally regulated such that only the smallest Tau isoform is expressed in fetal brain, contrary to the adult brain showing the expression...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Neuroinflammation and Neurodegeneration Mechanisms
Share to Neuroscience and Neural Engineering

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31522011
DOI: 10.1016/j.scr.2019.101541

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Detection of all adult Tau isoforms in a 3D culture model of iPSC-derived neuronsPMID 31522011Read ↗

Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT.Semantic proximity Read ↗

Engineered Cerebral Organoids Recapitulate Adult Tau Expression and Disease-relevant Changes in Tau SplicingSemantic proximity Read ↗

Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with<i>MAPT</i>mutationsSemantic proximity Read ↗

The TAU isoform 1N4R restores vulnerability of MAPT knockout human iPSC-derived neurons to Amyloid beta-induced neuronal dysfunctionSemantic proximity Read ↗

Pathological Progression Induced by the Frontotemporal Dementia-Associated R406W Tau Mutation in Patient-Derived iPSCsSemantic proximity Read ↗

Increased Tau Expression Correlates with Neuronal Maturation in the Developing Human Cerebral CortexSemantic proximity Read ↗

Tau depletion in human neurons mitigates Aβ-driven toxicitySemantic proximity Read ↗

Human Stem Cell-Derived Neurons: A System to Study Human Tau Function and DysfunctionSemantic proximity Read ↗

A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies.Semantic proximity Read ↗

A human iPSC model of tauopathies engineered for 4R tau isoform expression endogenously develops late-stage neuronal tau pathology.Semantic proximity Read ↗

The MAPT Isoform 0N3R Is Essential for Human Brain Development and Intolerant to Haploinsufficiency – Loss of Function as Disease Mechanism for TAU Associated DiseaseSemantic proximity Read ↗

Cultivation, differentiation, and lentiviral transduction of human induced pluripotent stem cell (hiPSC)-derived glutamatergic neurons for studying human TAUSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.