Article

Distinct Transcriptomic Responses to Aβ plaques, Neurofibrillary Tangles, and <i>APOE</i> in Alzheimer’s Disease

2023-03-21

Abstract excerpt

<h4>ABSTRACT</h4> <h4>INTRODUCTION</h4> Omics studies have revealed that various brain cell types undergo profound molecular changes in Alzheimer’s disease (AD) but the spatial relationships with plaques and tangles and APOE -linked differences remain unclear. <h4>METHODS</h4> We performed laser capture microdissection of Aβ plaques, the 50μm halo around them, tangles with the 50μm halo around them, and areas...

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Literature Corpus work: 53ebf61a-1cd9-5e8b-8674-11d4403f354c
DOI: 10.1101/2023.03.20.533303

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