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Immunosuppressive niche engineering at the onset of human colorectal cancer

4 Apr 2022

Abstract excerpt

The evolutionary dynamics of tumor initiation remain undetermined, and the interplay between neoplastic cells and the immune system is hypothesized to be critical in transformation. Colorectal cancer (CRC) presents a unique opportunity to study the transition to malignancy as pre-cancers (adenomas) and early-stage cancers are frequently resected. Here, we examine tumor-immune eco-evolutionary dynamics from...

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PMID: 35379804
DOI: 10.1038/s41467-022-29027-8

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