Article

Niche engineering drives early passage through an immune bottleneck in progression to colorectal cancer

2019-05-03

Abstract excerpt

Colorectal cancer develops from its precursor lesion, the adenoma. The immune system is hypothesized to be key in modulating progression, but tumor-immune eco-evolutionary dynamics remain uncharacterized. Here, we demonstrate a key role for immune evasion in the progression of human benign disease to colorectal cancer. We constructed a mathematical model of tumor-immune eco-evolutionary dynamics that predicted eco...

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Literature Corpus work: 0ddd60e7-c938-5768-a1ef-30bb685cdf00
DOI: 10.1101/623959

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