Article
Subclonal accumulation of immune escape mechanisms in microsatellite instability-high colorectal cancers.
British journal of cancer - 1 Oct 2023
Kobayashi Yuta, Niida Atsushi, Nagayama Satoshi, Saeki Koichi, Haeno Hiroshi, Takahashi Kazuki K, Hayashi Shuto, Ozato Yuki, Saito Hideyuki, Hasegawa Takanori, Nakamura Hiromi, Tobo Taro, Kitagawa Akihiro, Sato Kuniaki, Shimizu Dai, Hirata Hidenari, Hisamatsu Yuichi, Toshima Takeo, Yonemura Yusuke, Masuda Takaaki, Mizuno Shinichi, Kawazu Masahito, Kohsaka Shinji, Ueno Toshihide, Mano Hiroyuki, Ishihara Soichiro, Uemura Mamoru, Mori Masaki, Doki Yuichiro, Eguchi Hidetoshi, Oshima Masanobu, Suzuki Yutaka, Shibata Tatsuhiro, Mimori Koshi
Abstract excerpt
BACKGROUND: Intratumor heterogeneity (ITH) in microsatellite instability-high (MSI-H) colorectal cancer (CRC) has been poorly studied. We aimed to clarify how the ITH of MSI-H CRCs is generated in cancer evolution and how immune selective pressure affects ITH. METHODS: We reanalyzed public whole-exome sequencing data on 246 MSI-H CRCs. In addition, we performed a multi-region analysis from 6 MSI-H CRCs. To verify...
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