Article

Evolving neoantigen profiles in colorectal cancers with DNA repair defects

2019-06-11

Abstract excerpt

<h4>Background</h4> Neoantigens that arise as a consequence of tumour-specific mutations can be recognized by T lymphocytes leading to effective immune surveillance. In colorectal cancer (CRC) and other tumour types, a high number of neoantigens is associated with patient response to immune therapies. The molecular processes governing the generation of neoantigens and their turnover in cancer cells are poorly und...

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Literature Corpus work: 0362dc49-d09f-55b4-aadf-2a63f3c98834
DOI: 10.1101/667097

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