Article

Microglial sTREM2 limits dyskinesia and acts on TrkB to support circuit plasticity

2026-05-07

Abstract excerpt

Microglia continuously survey the brain and shape neuronal activity, but their contribution to experience-dependent synaptic plasticity is unclear. Levodopa-induced dyskinesia (LID) is a disabling complication of late-stage Parkinson’s disease (PD) that is linked to maladaptive striatal remodeling and is often assumed to reflect detrimental neuroinflammation. Here we identify a dyskinesia-associated microglial gen...

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Literature Corpus work: 7f174794-1ca6-5c17-b842-e9d009a91ba8
DOI: 10.64898/2026.05.06.723382

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