Article

Quinpirole ameliorates the dysfunction of microglia in human LRRK2-R1441G transgenic mice

2025-02-24

Abstract excerpt

Microglia-mediated neuroinflammation is a key contributor to Parkinson’s disease (PD) pathogenesis. Leucine-rich repeat kinase 2 (LRRK2), the leading genetic contributor to both familial and sporadic PD, has been implicated in driving this connection. However, its precise role remains incompletely understood due to technical challenges. To address this, we utilized a bacterial artificial chromosome (BAC) transgeni...

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Literature Corpus work: 1308df03-e6c6-5ac3-9028-c5c009a5a419
DOI: 10.1101/2025.02.23.639776

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