Article

Novel PSD95 reporter mice reveal medium spiny neuron subtype-specific synapse loss in PD and L-dopa induced dyskinesia and identify microglia mediated synapse removal as a therapeutic target for dyskinesia

2026-07-09

Abstract excerpt

<h4>Background</h4> L-Dopa remains the primary treatment for Parkinson’s disease (PD), but chronic administration frequently leads to L-Dopa-induced dyskinesia (LID). While D1 and D2 medium spiny neuron (MSN) specific structural changes on the spine level have been observed in the striatum of PD and LID, studying microglia mediated synapse loss has not been done to date. <h4>Methods</h4> Here we generated novel...

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Literature Corpus work: dd374a82-1c8a-5603-9b7d-1b272e3b3306
DOI: 10.64898/2026.07.05.736610

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