Article

Neurogenin-2 Reprograms Human Microglial Lineage Cells into Neurons In Vitro and in Chimeric Brains

2026-03-22

Abstract excerpt

Progressive neuronal loss is a hallmark of many neurological disorders, yet the adult human brain has a limited capacity for endogenous neuronal replacement. Direct neuronal reprogramming represents an alternative strategy for generating new neurons. Microglia, the brain’s resident immune cells, are uniquely positioned as candidate cellular substrates due to their abundance, self-renewal capacity, high motility, a...

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Literature Corpus work: 99229967-901e-5bbf-b82b-85e3c3489321
DOI: 10.64898/2026.03.19.712907

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