Article
Novel patterns of complex structural variation revealed across thousands of cancer genome graphs
2019-11-09
Abstract excerpt
<h4>Summary</h4> Cancer genomes often harbor hundreds of somatic DNA rearrangement junctions, many of which cannot be easily classified into simple (e.g. deletion, translocation) or complex (e.g. chromothripsis, chromoplexy) structural variant classes. Applying a novel genome graph computational paradigm to analyze the topology of junction copy number (JCN) across 2,833 tumor whole genome sequences (WGS), we intr...
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Identifiers and source
- Literature Corpus work
- d737fdfa-5f6f-52d1-a656-532d3f9e08ea
- DOI
- 10.1101/836296