Article
Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing.
Nature genetics - 1 Jun 2008
Campbell Peter J, Stephens Philip J, Pleasance Erin D, O'Meara Sarah, Li Heng, Santarius Thomas, Stebbings Lucy A, Leroy Catherine, Edkins Sarah, Hardy Claire, Teague Jon W, Menzies Andrew, Goodhead Ian, Turner Daniel J, Clee Christopher M, Quail Michael A, Cox Antony, Brown Clive, Durbin Richard, Hurles Matthew E, Edwards Paul A W, Bignell Graham R, Stratton Michael R, Futreal P Andrew
Abstract excerpt
Human cancers often carry many somatically acquired genomic rearrangements, some of which may be implicated in cancer development. However, conventional strategies for characterizing rearrangements are laborious and low-throughput and have low sensitivity or poor resolution. We used massively parallel sequencing to generate sequence reads from both ends of short DNA fragments derived from the genomes of two...
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