Article

Breakage fusion bridge cycles drive high oncogene copy number, but not intratumoral genetic heterogeneity or rapid cancer genome change

2023-12-13

Abstract excerpt

<h4>SUMMARY</h4> Oncogene amplification is a major driver of cancer pathogenesis. Breakage fusion bridge (BFB) cycles, like extrachromosomal DNA (ecDNA), can lead to high copy numbers of oncogenes, but their impact on intratumoral heterogeneity, treatment response, and patient survival are not well understood due to difficulty in detecting them by DNA sequencing. We describe a novel algorithm that detects and rec...

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Literature Corpus work: 7ef9ffec-b9ca-5c49-b3a5-fdfd8a349984
DOI: 10.1101/2023.12.12.571349

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