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An Atlas of Extrachromosomal DNA Structures Illuminates Its Evolution and Biogenesis in Cancer

2025-12-25

Abstract excerpt

Extrachromosomal circular DNA (ecDNA) is a prevalent driver of oncogene amplification across diverse types of cancers. Leveraging single-molecule long-read sequencing and a de novo circular genome assembler, ecLego3, we charted a comprehensive atlas of ecDNA structures from longitudinal pairs of primary and recurrent glioblastoma (GBM). Our approach resolved 23 ecDNA genomes representing major oncogenes associate...

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Literature Corpus work
db44467e-80e6-551c-9697-bfcb9561ced9
DOI
10.64898/2025.12.24.696443
Open publication

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An Atlas of Extrachromosomal DNA Structures Illuminates Its Evolution and Biogenesis in CancerDOI 10.64898/2025.12.24.696443
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