Article

Insights into the Mechanisms and Structure of Breakage-Fusion-Bridge Cycles in Cervical Cancer using Long-Read Sequencing

2023-08-22

Abstract excerpt

<h4>Summary</h4> Cervical cancer is caused by human papillomavirus (HPV) infection, has few approved targeted therapeutics, and is the most common cause of cancer death in low-resource countries. We characterized 19 cervical and four head and neck cell lines using long-read DNA and RNA sequencing and identified the HPV types, HPV integration sites, chromosomal alterations, and cancer driver mutations. Structural v...

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Literature Corpus work: 11816d7f-3b07-5d8e-9cfd-bf8d1f880093
DOI: 10.1101/2023.08.21.23294276

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