Article

Improving performance of polygenic risk scores for hypertension across two ancestry groups

2025-11-07

Abstract excerpt

Polygenic risk score (PRS) methods are evolving, and the benefit of adding functional annotations to the variant weights has been especially promising. However, less attention has been given to how the linkage disequilibrium (LD) reference panel used affects the score performance. In the current study, we compared two Bayesian approaches, one that incorporates functional annotations (LDpred-funct) and one that doe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7eda4889-7a96-588e-b837-7f590c1325c4
DOI: 10.1101/2025.11.05.25339527

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Improving performance of polygenic risk scores for hypertension across two ancestry groupsDOI 10.1101/2025.11.05.25339527Read

Improving performance of polygenic risk scores for hypertension across two ancestry groups.Semantic proximity Read

Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups.Semantic proximity Read

Polygenic risk score portability for common diseases across genetically diverse populationsSemantic proximity Read

A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood.Semantic proximity Read

Optimizing and benchmarking polygenic risk scores with GWAS summary statisticsSemantic proximity Read

Polygenic risk score portability for common diseases across genetically diverse populations.Semantic proximity Read

Optimizing and benchmarking polygenic risk scores with GWAS summary statistics.Semantic proximity Read

Improving on polygenic scores across complex traits using select and shrink with summary statisticsSemantic proximity Read

Polygenic risk score prediction accuracy convergenceSemantic proximity Read

PGS Browser: a public platform for personalized polygenic score analysis and interpretation.Semantic proximity Read

Global biobank analyses provide lessons for developing polygenic risk scores across diverse cohortsSemantic proximity Read

S4-Multi: enhancing polygenic score prediction in ancestrally diverse populationsSemantic proximity Read