Article
Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups.
Nature communications - 2 Jun 2023
Kurniansyah Nuzulul, Goodman Matthew O, Khan Alyna T, Wang Jiongming, Feofanova Elena, Bis Joshua C, Wiggins Kerri L, Huffman Jennifer E, Kelly Tanika, Elfassy Tali, Guo Xiuqing, Palmas Walter, Lin Henry J, Hwang Shih-Jen, Gao Yan, Young Kendra, Kinney Gregory L, Smith Jennifer A, Yu Bing, Liu Simin, Wassertheil-Smoller Sylvia, Manson JoAnn E, Zhu Xiaofeng, Chen Yii-Der Ida, Lee I-Te, Gu C Charles, Lloyd-Jones Donald M, Zöllner Sebastian, Fornage Myriam, Kooperberg Charles, Correa Adolfo, Psaty Bruce M, Arnett Donna K, Isasi Carmen R, Rich Stephen S, Kaplan Robert C, Redline Susan, Mitchell Braxton D, Franceschini Nora, Levy Daniel, Rotter Jerome I, Morrison Alanna C, Sofer Tamar
Abstract excerpt
We assess performance and limitations of polygenic risk scores (PRSs) for multiple blood pressure (BP) phenotypes in diverse population groups. We compare "clumping-and-thresholding" (PRSice2) and LD-based (LDPred2) methods to construct PRSs from each of multiple GWAS, as well as multi-PRS approaches that sum PRSs with and without weights, including PRS-CSx. We use datasets from the MGB Biobank, TOPMed study, UK...
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