Article
A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood.
Nature communications - 21 Jun 2022
Kurniansyah Nuzulul, Goodman Matthew O, Kelly Tanika N, Elfassy Tali, Wiggins Kerri L, Bis Joshua C, Guo Xiuqing, Palmas Walter, Taylor Kent D, Lin Henry J, Haessler Jeffrey, Gao Yan, Shimbo Daichi, Smith Jennifer A, Yu Bing, Feofanova Elena V, Smit Roelof A J, Wang Zhe, Hwang Shih-Jen, Liu Simin, Wassertheil-Smoller Sylvia, Manson JoAnn E, Lloyd-Jones Donald M, Rich Stephen S, Loos Ruth J F, Redline Susan, Correa Adolfo, Kooperberg Charles, Fornage Myriam, Kaplan Robert C, Psaty Bruce M, Rotter Jerome I, Arnett Donna K, Morrison Alanna C, Franceschini Nora, Levy Daniel, Sofer Tamar
Abstract excerpt
In a multi-stage analysis of 52,436 individuals aged 17-90 across diverse cohorts and biobanks, we train, test, and evaluate a polygenic risk score (PRS) for hypertension risk and progression. The PRS is trained using genome-wide association studies (GWAS) for systolic, diastolic blood pressure, and hypertension, respectively. For each trait, PRS is selected by optimizing the coefficient of variation (CV) across...
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