Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Improving performance of polygenic risk scores for hypertension across two ancestry groups.

PloS one - 1 Jan 2026

Irvin Marguerite R, Srinivasasainagendra Vinodh, Armstrong Nicole D, Patki Amit, Broeckel Ulrich, Wang Zhe, Lange Leslie A, Limdi Nita A, Huerta-Chagoya Alicia, Kim Joohyun, Ng Maggie C Y, Mercader Josep M, Tiwari Hemant K

Abstract excerpt

Polygenic risk score (PRS) methods are evolving, and the benefit of adding functional annotations to the variant weights has been especially promising. However, less attention has been given to how the linkage disequilibrium (LD) reference panel used affects the score performance. In the current study, we compared two Bayesian approaches, one that incorporates functional annotations (LDpred-funct) and one that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bayes Theorem
Share to Black or African American

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Risk Score

Share to Genome-Wide Association Study

Share to Hypertension

Share to Linkage Disequilibrium

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 42497180
DOI: 10.1371/journal.pone.0353311
PMCID: PMC13399276

Genes

CS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Improving performance of polygenic risk scores for hypertension across two ancestry groups.PMID 42497180Read ↗

Improving performance of polygenic risk scores for hypertension across two ancestry groupsSemantic proximity Read ↗

Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups.Semantic proximity Read ↗

Polygenic risk score portability for common diseases across genetically diverse populationsSemantic proximity Read ↗

A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood.Semantic proximity Read ↗

Polygenic risk score portability for common diseases across genetically diverse populations.Semantic proximity Read ↗

Optimizing and benchmarking polygenic risk scores with GWAS summary statisticsSemantic proximity Read ↗

Optimizing and benchmarking polygenic risk scores with GWAS summary statistics.Semantic proximity Read ↗

PGS Browser: a public platform for personalized polygenic score analysis and interpretation.Semantic proximity Read ↗

S4-Multi: enhancing polygenic score prediction in ancestrally diverse populationsSemantic proximity Read ↗

Polygenic risk score prediction accuracy convergenceSemantic proximity Read ↗

Improving on polygenic scores across complex traits using select and shrink with summary statisticsSemantic proximity Read ↗

Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.