Article

PLCG2 variant p.P522R - associated with healthy aging- may reduce the aging of the human immune system

2022-08-24

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Phospholipase C gamma 2 (PLCγ2) is encoded by the <italic>PLCG2</italic> gene. A single-nucleotide polymorphism (p.P522R) associates with protection against several dementia subtypes and with increased likelihood of longevity. Cell lines and animal models indicated that p.P522R is a functional hypermorph. We aimed to confirm this in human peripheral immune cells...

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Literature Corpus work: 7ec31c9d-86c6-57ee-8c88-f5d4bd8eb162
DOI: 10.21203/rs.3.rs-1929710/v1

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