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Article

Alzheimer's disease-associated protective variant Plcg2-P522R modulates peripheral macrophage function in a sex-dimorphic manner.

Journal of neuroinflammation - 1 Nov 2024

Staley Hannah A, Jernigan Janna E, Bolen MacKenzie L, Titus Ann M, Neighbarger Noelle, Cole Cassandra, Menees Kelly B, Wallings Rebecca L, Tansey Malú Gámez

Abstract excerpt

Genome-wide association studies have identified a protective mutation in the phospholipase C gamma 2 (PLCG2) gene which confers protection against Alzheimer's disease (AD)-associated cognitive decline. Therefore, PLCG2, which is primarily expressed in immune cells, has become a target of interest for potential therapeutic intervention. The protective allele, known as P522R, has been shown to be hyper-morphic in...

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Identifiers

PMID: 39487477
DOI: 10.1186/s12974-024-03271-9
PMCID: PMC11529260

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Alzheimer's disease-associated protective variant Plcg2-P522R modulates peripheral macrophage function in a sex-dimorphic manner.PMID 39487477Read ↗

Alzheimer’s disease-associated protective variant Plcg2-P522R modulates peripheral macrophage function in a sex-dimorphic mannerSemantic proximity Read ↗

The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions.Semantic proximity Read ↗

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The Alzheimer’s disease-associated protective <i>Plcγ2</i> -P522R variant promotes beneficial microglial functionsSemantic proximity Read ↗

Alzheimer’s disease Phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorphSemantic proximity Read ↗

Genetic Variants of Phospholipase C-γ2 Confer Altered Microglial Phenotypes and Differential Risk for Alzheimer’s DiseaseSemantic proximity Read ↗

Heterozygous expression of the Alzheimer’s disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapsesSemantic proximity Read ↗

<i>PLCG2</i> as a Risk Factor for Alzheimer’s DiseaseSemantic proximity Read ↗

Protective variant in PLCγ2 mitigates Alzheimer’s disease-associated pathologies via enhancing beneficial microglia functionsSemantic proximity Read ↗

PLCG2 variant p.P522R - associated with healthy aging- may reduce the aging of the human immune systemSemantic proximity Read ↗

PLCG2 signaling and genetic resilience in Alzheimer's disease.Semantic proximity Read ↗

The Alzheimer’s disease protective P522R variant of <i>PLCG2</i> , consistently enhances stimulus-dependent PLCγ2 activation, depleting substrate and altering cell functionSemantic proximity Read ↗

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