Article

Identification of the Lipid Oxygen Radical Defense pathway and its epigenetic control

2025-05-28

Abstract excerpt

<title>Abstract</title> <p>Membrane phospholipids are vulnerable to oxidative radicals, and uncontrolled lipid peroxidation affects cell viability. Cells have evolved quality control and defense mechanisms, of which the genetic regulation of is not fully understood. Here, we identify the Lipid Oxygen Radical Defense (LORD) pathway. It is epigenetically repressed, by a complex comprising the KRAB-zinc finger prote...

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Literature Corpus work: 7ea1e22e-5cb1-5629-b7a0-9a0c8ee95840
DOI: 10.21203/rs.3.rs-6339649/v1

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