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Inactivation of RIP3 kinase sensitizes to 15LOX/PEBP1-mediated ferroptotic death

10 Jan 2022

Abstract excerpt

Ferroptosis and necroptosis are two pro-inflammatory cell death programs contributing to major pathologies and their inhibition has gained attention to treat a wide range of disease states. Necroptosis relies on activation of RIP1 and RIP3 kinases. Ferroptosis is triggered by oxidation of polyunsaturated phosphatidylethanolamines (PUFA-PE) by complexes of 15-Lipoxygenase (15LOX) with...

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PMID: 35101798
DOI: 10.1016/j.redox.2022.102232

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