Article
NFE2L1-mediated proteasome function protects from ferroptosis
2021-12-12
Abstract excerpt
<h4>Objective</h4> Ferroptosis continues to emerge as a novel modality of cell death with important therapeutic implications for a variety of diseases, most notably cancer and degenerative diseases. While susceptibility, initiation, and execution of ferroptosis have been linked to reprogramming of cellular lipid metabolism, imbalances in iron-redox homeostasis, and aberrant mitochondrial respiration, the detailed...
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Identifiers and source
- Literature Corpus work
- dafd0af0-b651-506a-9b11-5209e893b720
- DOI
- 10.1101/2021.12.12.472274