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Ferroptosis: mechanisms and therapeutic targets

20 Nov 2024

Abstract excerpt

Ferroptosis is a nonapoptotic form of cell death characterized by iron-dependent lipid peroxidation in membrane phospholipids. Since its identification in 2012, extensive research has unveiled its involvement in the pathophysiology of numerous diseases, including cancers, neurodegenerative disorders, organ injuries, infectious diseases, autoimmune conditions, metabolic disorders, and skin diseases. Oxidizable...

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PMID: 39568772
DOI: 10.1002/mco2.70010

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